Ethyl 2-Aminothiazole-5-Carboxylate CAS 32955-21-8 Purity >98.0% (HPLC) Dasatinib Intermediate
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Ethyl 2-Aminothiazole-5-Carboxylate (CAS: 32955-21-8) with high quality, intermediate of Dasatinib (CAS: 302962-49-8) and Dasatinib Monohydrate (CAS: 863127-77-9). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Dasatinib intermediates, Please contact: alvin@ruifuchem.com
| Chemical Name | Ethyl 2-Aminothiazole-5-Carboxylate |
| Synonyms | 2-Aminothiazole-5-Carboxylic Acid Ethyl Ester; 2-Amino-5-Thiazole carboxylic Acid Ethyl Ester; 2-Amino-5-(Ethoxycarbonyl)thiazole; Ethyl 2-Amino-1,3-Thiazole-5-Carboxylate; Ethyl 2-Amino-5-Thiazolecarboxylate |
| Stock Status | In Stock, Production Capacity 15 Tons per Year |
| CAS Number | 32955-21-8 |
| Molecular Formula | C6H8N2O2S |
| Molecular Weight | 172.20 g/mol |
| Melting Point | 159.0 to 163.0℃ |
| Density | 1.336±0.06 g/cm3 |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Light Sensitive, Moisture Sensitive, Heat Sensitive |
| Solubility | Insoluble in Water. Slightly Soluble in Methanol |
| Storage Condition | 2~8℃ |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | Light Brown to Off-White Powder or Crystals | Complies |
| Melting Point | 159.0~163.0℃ | 161.2℃ |
| Water by Karl Fischer | <0.50% | 0.09% |
| Residue on Ignition | <0.20% | 0.05% |
| Purity / Analysis Method | >98.0% (HPLC Area) | 99.58% |
| Infrared Spectrum | Consistent with Structure | Complies |
| 1H NMR Spectrum | Consistent with Structure | Complies |
| Conclusion | The product has been tested and complies with the given specifications | |
| Application: Intermediate of Dasatinib (CAS: 302962-49-8) and Dasatinib Monohydrate (CAS: 863127-77-9). | ||
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Method of Analysis (CAS: 32955-21-8)
(HPLC) Method for Chemical Purity
Instrument Model: Agilent Technologies 1120 Compact LC
Column: YMC-Pack ODS-A(150*6.0)mml.D.S-5um12nm
Wavelength: 300nm
Mobile Phase: MeOH:(water+0.5%TEA)=65:35
Sample Concentration: 200μg/ml
Injection Volume: 20μL
Flow Rate: 1ml/min
Solvent: MeOH:Water=60:40 (V/V)
Column Temperature: At ambient temperature
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Hazard Symbols Xi - Irritant
Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany 2
HS Code 2934109099
Hazard Class IRRITANT
Ethyl 2-Aminothiazole-5-Carboxylate (CAS: 32955-21-8) with high quality, intermediate of Dasatinib (CAS: 302962-49-8) and Dasatinib Monohydrate (CAS: 863127-77-9).
May 2009, the US Food and Drug Administration (FDA) formally approved the sale of Dasatinib. Dasatinib has been clinically used for the treatment of various chronic myeloid leukemia (CML), including treatment of chronic myeloid leukemia which is resistant
Dasatinib is an oral Bcr-Abl tyrosine kinase inhibitor (inhibits the "Philadelphia chromosome") and Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is being evaluated for use in numerous other cancers, including advanced prostate cancer.
Dasatinib is a cancer medicine that slows the growth and spread of cancer cells in the body. Dasatinib is suitable for chronic myeloid leukemia that is resistant or intolerant to treatment regimens including Imatinib Mesylate.
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